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The Shocking Truth: Can Cortisone Shots Cause Insomnia?

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  Can Cortisone Shots Cause Insomnia? What You Need to Know Cortisone injections are widely used to relieve pain and inflammation in joints, tendons, and soft tissues. For many people, a single shot can mean weeks—or even months—of comfort. But some patients notice an unexpected side effect after their injection: difficulty falling or staying asleep. Could cortisone shots actually cause insomnia? Let’s look at what the science and clinical experience say. How Cortisone Works in the Body Cortisone is a corticosteroid—an artificial version of hormones your adrenal glands naturally produce during stress. When injected, cortisone reduces inflammation locally, calming pain and swelling. Although much of the medicine stays near the target joint, a small amount can enter the bloodstream and briefly mimic the effects of natural stress hormones. Because corticosteroids act on multiple systems—immune, endocrine, and nervous—some short-term systemic effects are possible, even from a local sho...